Definitely make a plan and have backups in mind, even if it's rough. It will help if you get shut out of a venue.
Also, logistics are very important. The big theaters (Bigou, Tennessee, Civic Auditorium) and some of the churches are clustered downtown. Most of the smaller venues (Standard, Mill & Mine, The Point) are in the uptown area. The town is very walkable, but the trek up and down Gay St (the main artery though town) can take 15 minutes or more to go from one end to the other. They have a shuttle, but it's not very efficient.