Very interesting news piece on BBC radio yesterday about the positive effects some of these weight loss drugs are having on other long term illnesses.
I can't remember the details but it was a highly respected medical academic, one who led UK COVID vaccine effort, that was being so positive about them. Sounded very encouraging
This isn't the radio piece nor the academic I referenced but looks like fundamentally the same story on the BBC website
https://www.bbc.co.uk/news/articles/c9d5pq4y5wpo
Obvious caveats as with all medical trials but nonetheless potentially very interesting
And just as an aside, to @Pim's point about exercise/calorie intake being the sole weight loss strategy, not everyone is in position to physically exercise to any great extent. Yes they then need to be more careful with their diet but some disabling health conditions have physical and mental consequences not always in the individual's control or at the very least very difficult to control I leave that there and say no more.